Abstract |
Liver iron concentration (LIC) assessment by magnetic resonance imaging (MRI) remains the gold standard to diagnose iron overload and guide iron chelation therapy in patients with non-transfusion-dependent thalassaemia (NTDT). However, limited access to MRI technology and expertise worldwide makes it practical to also use serum ferritin assessments. The THALASSA (assessment of Exjade(®) in non-transfusion-dependent THALASSemiA patients) study assessed the efficacy and safety of deferasirox in iron-overloaded NTDT patients and provided a large data set to allow exploration of the relationship between LIC and serum ferritin. Using data from screened patients and those treated with deferasirox for up to 2 years, we identified clinically relevant serum ferritin thresholds (for when MRI is unavailable) for the initiation of chelation therapy (>800 μg/l), as well as thresholds to guide chelator dose interruption (<300 μg/l) and dose escalation (>2000 μg/l). (clinicaltrials.gov identifier: NCT00873041).
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Authors | Ali T Taher, John B Porter, Vip Viprakasit, Antonis Kattamis, Suporn Chuncharunee, Pranee Sutcharitchan, Noppadol Siritanaratkul, Raffaella Origa, Zeynep Karakas, Dany Habr, Zewen Zhu, Maria Domenica Cappellini |
Journal | British journal of haematology
(Br J Haematol)
Vol. 168
Issue 2
Pg. 284-90
(Jan 2015)
ISSN: 1365-2141 [Electronic] England |
PMID | 25212456
(Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd. |
Chemical References |
- Benzoates
- Iron Chelating Agents
- Triazoles
- Ferritins
- Iron
- Deferasirox
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Topics |
- Adolescent
- Adult
- Benzoates
(administration & dosage)
- Deferasirox
- Double-Blind Method
- Female
- Ferritins
(blood)
- Humans
- Iron
(metabolism)
- Iron Chelating Agents
(administration & dosage)
- Liver
(metabolism)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Thalassemia
(blood, drug therapy)
- Triazoles
(administration & dosage)
- Young Adult
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