Subfoveal choroidal thickness and glaucoma. The Beijing Eye Study 2011.

Abstract

PURPOSE:

To examine subfoveal choroidal thickness (SFCT) in eyes with glaucoma, using enhanced depth imaging spectral domain optical coherence tomography.

METHODS:

The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of SFCT, and assessment of fundus photographs for presence of glaucoma. In addition, the group of patients with chronic angle-closure glaucoma (ACG) from the Beijing Eye Study (n = 37) was merged with a group of patients with chronic ACG from the Tongren hospital (n = 52).

RESULTS:

Assessments of SFCT and glaucoma were available for 3232 (93.2%) subjects. After adjusting for age, axial length, gender, anterior chamber and lens thickness, SFCT was not significantly associated with presence of glaucoma (P = 0.08; regression coefficient B:-15.7). As a corollary, in logistic regression analysis with adjustment for age, axial length and intraocular pressure, presence of glaucoma was not significantly associated with SFCT (P = 0.20). If only open-angle glaucoma was considered, multivariate analysis revealed no significant association between SFCT and presence of open-angle glaucoma (P = 0.44). As a corollary, in logistic regression analysis, open-angle glaucoma was not significantly associated with SFCT (P = 0.91). In a similar manner if only ACG was taken into account, SFCT was not significantly associated with the presence of ACG (P = 0.27) in multivariate analysis. As a corollary in binary regression analysis, presence of ACG was not significantly associated with SFCT (P = 0.27).

CONCLUSIONS:

In multivariate analysis with adjustment for age, axial length, gender, anterior chamber and lens thickness, neither OAG nor ACG was associated with an abnormal SFCT.

• Authors: Ya Xing Wang, Liang Xu, Lei Shao, Ya Qin Zhang, Hua Yang, Jin Da Wang, Jost B Jonas, Wen Bin Wei
• Journal: PloS one (PLoS One) Vol. 9 Issue 9 Pg. e107321 ( 2014) ISSN: 1932-6203 [Electronic] United States
• PMID: 25210857 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Aged, 80 and over
• Choroid (pathology)
• Cross-Sectional Studies
• Female
• Fovea Centralis (pathology)
• Glaucoma, Angle-Closure (pathology)
• Glaucoma, Open-Angle (pathology)
• Humans
• Male
• Middle Aged
• Tomography, Optical Coherence