Abstract | OBJECTIVE: MATERIALS AND METHODS: Electronic search of PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases was conducted to select studies about KLT injection combined with chemotherapy versus chemotherapy alone in the treatment of advanced NSCLC. The pooled risk ratio (RR) and its 95% confidence interval (95% CI) for objective response rate (ORR), Karnofsky (KPS) score improvement and nausea and vomiting were calculated by Stata11.0 statistical software. RESULT: Finally, we included 34 clinical trials in this meta-analysis. The pooled results suggested that KLT injection combined with systematic chemotherapy can significantly increase the objective response rate (ORR) [RR = 1.35, 95% CI: 1.23-1.48, (Z = 6.43, P = 0.000)], the quality of patients' life (KSP improvement) [RR = 2.04, 95% CI: 1.79-2.33, (Z = 10.57, P = 0.000)] and decrease the risk ratio of gastrointestinal reaction [RR = 0.53, 95% CI: 0.42-0.66, (Z = 5.53, P = 0.000)] compared with chemotherapy alone. CONCLUSION: KLT injection combined with chemotherapy can improve the short-term efficacy, performance status and decrease the risk of gastrointestinal reaction compared with systematic chemotherapy alone.
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Authors | Xiaohong Liu, Qinghui Yang, Yuling Xi, Kewei Yu, Weizhen Wang, Xiangmei Zhao, Xiaoge Kou |
Journal | Journal of cancer research and therapeutics
(J Cancer Res Ther)
Vol. 10 Suppl 1
Pg. 46-51
(Aug 2014)
ISSN: 1998-4138 [Electronic] India |
PMID | 25207891
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Antineoplastic Agents
- Drugs, Chinese Herbal
- kang-lai-te
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Topics |
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, pathology)
- Drug Therapy
- Drugs, Chinese Herbal
(administration & dosage, adverse effects)
- Humans
- Karnofsky Performance Status
- Neoplasm Staging
- PubMed
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