Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress.

Abstract

Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.

• Authors: Tao Lei, Haifeng Li, Zhen Fang, Junbin Lin, Shanshan Wang, Lingyun Xiao, Fan Yang, Xin Liu, Junjian Zhang, Zebo Huang, Weijing Liao
• Journal: Neural regeneration research (Neural Regen Res) Vol. 9 Issue 3 Pg. 260-7 (Feb 01 2014) ISSN: 1673-5374 [Print] India
• PMID: 25206810 (Publication Type: Journal Article)