Abstract | BACKGROUND/OBJECTIVES: Detecting the presence of coronary artery disease (CAD) is critically important in managing patients with heart failure of uncertain cause. The recently introduced 123I- BMIPP/201TlCl dual myocardial single-photon emission computed tomography (dual SPECT) is potentially a non-invasive diagnostic tool in detecting ischemic heart disease. The aim of our study is to evaluate the efficacy of detecting CAD by dual SPECT in patients with heart failure. METHODS: We studied 501 consecutive patients (366 males, mean age 68±12 years) who were admitted because of heart failure between January 2005 and April 2009. In all patients, the dual SPECT was performed in clinically stabilized states, followed by coronary angiography within 1 week. The polar map of the SPECT image was divided into 17 segments, each scored on a scale of 0-4 based on segmental percent uptake. The mismatch score was defined as the difference between 123I-BMIPP defect score and 201TlCI defect score. The uptake of 201TlCl and 123I-BMIPP was analyzed quantitatively using the Heart Score View software. RESULTS: The 201TlCI defect score and mismatch score were significantly higher in CAD patients than in non-CAD patients. The receiver operating characteristic (ROC) curve revealed that the mismatch score was a significantly more effective marker in detecting the presence of CAD than 201TlCl defect score (area under the curve: 0.84 versus 0.73, p<0.05). Using the mismatch score, the sensitivity and specificity of dual SPECT in detecting CAD were 84% and 83%, respectively. CONCLUSION: Dual SPECT is a useful non-invasive procedure for the detection of CAD in patients with heart failure.
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Authors | Hajime Abe, Nobuo Iguchi, Yuko Utanohara, Kanki Inoue, Itaru Takamisawa, Atsushi Seki, Kouhei Tanizaki, Norihiko Takeda, Tetsuya Tohbaru, Ryuta Asano, Masatoshi Nagayama, Morimasa Takayama, Jun Umemura, Tetsuya Sumiyoshi, Hitonobu Tomoike |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 176
Issue 3
Pg. 969-74
(Oct 20 2014)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 25205480
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Fatty Acids
- Iodine Radioisotopes
- Iodobenzenes
- Thallium Radioisotopes
- iodofiltic acid
- thallium chloride
- Thallium
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Coronary Artery Disease
(complications, diagnosis)
- Fatty Acids
- Female
- Heart Failure
(complications, diagnostic imaging)
- Humans
- Iodine Radioisotopes
- Iodobenzenes
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Thallium
- Thallium Radioisotopes
- Tomography, Emission-Computed, Single-Photon
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