Successful use of rFVIIa for major breast surgery prophylaxis in congenital factor VII deficiency: a case report.

Abstract

INTRODUCTION:

Factor VII deficiency is a rare cause of haemorrhagic syndrome. The Authors describe a case of a 46 years old patient with congenital factor VII deficiency that successfully underwent breast surgery after treatment with Novoseven® before the procedure.

MATERIALS AND METHODS:

The AA used the schedule reported below to value the levels of PT and aPTT in the patient. Blood Collection: Venous blood from patient and control was collected in glass tubes for routine serum preparation and into plastic tubes (0.129 M sodium citrate, Becton-Dickinson Vacutainer Systems) in a ratio of blood to anticoagulant of 9:1. Platelet Poor Plasma (PPP) was obtained by centrifugation at 4.000 x g for 15 minutes at room temperature. The plasma was recentrifuged for another 10 min at 12000 g to fully eliminate platelet concentration. A normal control plasma pool was prepared by mixing equal volumes of platelet-free plasma obtained from at least 50 normal volunteers. Prothrombin time (PT) was measured with Recombiplastin (IL, Milano Italy). Activated partial thromboplastin times (APTT) was measured with APTT-SP (IL, Milano Italy). They were performed on the coagulation analyzer ACL 1000 (IL, Milano Italy).

RESULTS:

The results were interpreted from the ratio of the patient times to the normal control times (Table I).

CONCLUSION:

The infusion of Novoseven solved the clotting problems enabling the surgical procedure, without risks for the patient.

• Authors: Antonio Varricchio, Michela Schettino, Antonio Ciampa, Carlo Iannace, Domenico Lo Conte, Lorenzo Di Libero, Bernadette Donnarumma, Raffaella Vigorito, Mariolina Lepore
• Journal: Annali italiani di chirurgia (Ann Ital Chir) Vol. 85 Issue ePub (Jun 25 2014) ISSN: 2239-253X [Electronic] Italy
• PMID: 25204840 (Publication Type: Case Reports, Journal Article)

Chemical References

• Recombinant Proteins
• recombinant FVIIa
• Factor VIIa

Topics

• Breast Neoplasms (complications, surgery)
• Factor VII Deficiency (complications)
• Factor VIIa (therapeutic use)
• Female
• Humans
• Middle Aged
• Paget's Disease, Mammary (complications, surgery)
• Postoperative Hemorrhage (etiology, prevention & control)
• Preoperative Care
• Recombinant Proteins (therapeutic use)