Sacral resection with pelvic exenteration for advanced primary and recurrent pelvic cancer: a single-institution experience of 100 sacrectomies.

Abstract

BACKGROUND:

Recurrent and advanced primary pelvic cancers present a complex clinical issue requiring multidisciplinary care and radical extended surgery. Sacral resection is necessary for tumors that invade posteriorly but is associated with increased morbidity and mortality.

OBJECTIVE:

This study aimed to analyze the morbidity and survival associated with pelvic exenteration involving sacrectomy for advanced pelvic cancers at a single institution.

DESIGN:

This study used patient demographics, operative and pathologic reports, and prospective survival data to determine factors affecting patient outcomes.

SETTINGS:

Data were collected for patients who had operations between July 1998 and April 2012 at Royal Prince Alfred Hospital.

PATIENTS:

One hundred patients underwent pelvic exenteration with a sacrectomy for advanced pelvic cancers. Sacrectomy was performed for 18 primary and 61 recurrent rectal cancers, 17 anal cancers, and 4 other cancers.

MAIN OUTCOME MEASURES:

This study looked at postoperative major and minor morbidity rates, as well as disease-free and overall survival rates after sacral resection. It compared the outcomes of high sacrectomy (at or above S2) versus low sacrectomy.

RESULTS:

Clear margins were achieved in 72 of 100 patients. The overall complication rate was 74% (43% major and 67% minor) with no 30-day or in-hospital mortality. Estimated overall and disease-free survival rates after curative resection were 38% and 30% at 5 years. Involved margins (p = 0.006), lymph node involvement (p = 0.008), and anterior organ invasion (p = 0.008) had a negative impact on patient survival. High sacrectomy increased the incidence of neurologic deficit postoperatively (p = 0.04) but did not alter the rate of R0 resection or patient survival.

LIMITATIONS:

Retrospective data were required to analyze patient morbidity, as well as operative and pathologic factors.

CONCLUSIONS:

This series supports sacral resection for curative surgery in advanced pelvic cancers, achieving excellent R0 and long-term survival rates. Cortical bone invasion and high sacrectomy were not contraindications to surgery and had acceptable outcomes.

• Authors: Tony Milne, Michael J Solomon, Peter Lee, Jane M Young, Paul Stalley, James D Harrison, Kirk K S Austin
• Journal: Diseases of the colon and rectum (Dis Colon Rectum) Vol. 57 Issue 10 Pg. 1153-61 (Oct 2014) ISSN: 1530-0358 [Electronic] United States
• PMID: 25203370 (Publication Type: Journal Article)

Topics

• Adenocarcinoma (secondary, surgery)
• Adult
• Aged
• Anastomotic Leak (etiology)
• Anus Neoplasms (pathology, surgery)
• Carcinoma, Squamous Cell (secondary, surgery)
• Disease-Free Survival
• Female
• Follow-Up Studies
• Humans
• Ileus (etiology)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (surgery)
• Pelvic Exenteration (adverse effects)
• Peripheral Nerve Injuries (etiology)
• Rectal Neoplasms (pathology, surgery)
• Retrospective Studies
• Sacrum (pathology, surgery)
• Surgical Wound Infection (etiology)
• Survival Rate
• Urinary Incontinence (etiology)
• Urinary Retention (etiology)
• Urinary Tract Infections (etiology)