Preventive effects of probiotic bacteria Lactobacillus plantarum and dietary fiber in chemically-induced mammary carcinogenesis.

Abstract

AIM:

The purpose of the present study was to evaluate the chemopreventive efficacy of a new probiotic bacterial strain, Lactobacillus plantarum LS/07 (PRO), prebiotic oligofructose-enriched inulin (PRE) and PRO-PRE combination in a rat model of breast cancer.

MATERIALS AND METHODS:

Mammary carcinogenesis was induced by 7,12-dimethylbenz[a]anthracene (DMBA). Daily oral administration of PRO (at a dose of 8.4×10(8) c.f.u./rat) and PRE (in the diet, 20 g/kg) started two weeks before the first DMBA dose and lasted until the end of the experiment (16 weeks).

RESULTS:

Administration of PRO, PRE and PRO-PRE combination significantly suppressed the tumor frequency, increased Cd4(+) T-cells in tumor tissue and reduced serum tumor necrosis factor-α concentration. In PRO and PRO-PRE groups, the decline of Cd8(+) T-cells in blood and their increase in tumor tissue was observed.

CONCLUSION:

Long-term administration of Lactobacillus plantarum LS/07 with and without inulin is effective against breast cancer, at least partially, through immunomodulatory mechanisms.

• Authors: Monika Kassayová, Nikita Bobrov, Ladislav Strojný, Terézia Kisková, Jaromír Mikeš, Vlasta Demečková, Peter Orendáš, Bianka Bojková, Martin Péč, Peter Kubatka, Alojz Bomba
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 9 Pg. 4969-75 (Sep 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 25202079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Cytokines
• Dietary Fiber
• 9,10-Dimethyl-1,2-benzanthracene
• Inulin

Topics

• 9,10-Dimethyl-1,2-benzanthracene (adverse effects)
• Animals
• Cell Transformation, Neoplastic (chemically induced)
• Cytokines (biosynthesis)
• Diet
• Dietary Fiber (administration & dosage)
• Disease Models, Animal
• Female
• Inulin (administration & dosage)
• Lactobacillus plantarum (physiology)
• Mammary Neoplasms, Experimental (immunology, metabolism, pathology, prevention & control)
• Neoplasm Invasiveness
• Neoplasm Staging
• Probiotics (administration & dosage)
• Rats
• T-Lymphocyte Subsets (immunology, metabolism)