Abstract | AIM: MATERIALS AND METHODS: RESULTS: The inhibitory effects of HL-25 on the growth of WiDr cells along with apoptosis were assessed in vitro. Remarkable inhibitory effects of HL-25 for the liver metastasis of colorectal cancer cells along with apoptosis were revealed on the basis of histological analysis. Prolonged survival was attained for the xenograft mouse model of colorectal cancer after treatment with HL-25 in vivo. CONCLUSION:
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Authors | Hideaki Ichihara, Shinichiro Nakagawa, Yusuke Matsuoka, Kenshi Yoshida, Yoko Matsumoto, Ryuichi Ueoka |
Journal | Anticancer research
(Anticancer Res)
Vol. 34
Issue 9
Pg. 4701-8
(Sep 2014)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 25202047
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Liposomes
- polyoxyethylene(25)dodecyl ether
- Polyethylene Glycols
- Dimyristoylphosphatidylcholine
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Topics |
- Animals
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Colorectal Neoplasms
(drug therapy, metabolism, pathology)
- Dimyristoylphosphatidylcholine
(chemistry, pharmacology)
- Disease Models, Animal
- Female
- Humans
- Liposomes
(chemistry, pharmacology)
- Liver Neoplasms
(drug therapy, pathology, secondary)
- Mice
- Nanomedicine
- Polyethylene Glycols
(chemistry, pharmacology)
- Tumor Burden
(drug effects)
- Xenograft Model Antitumor Assays
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