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Ultrasound as predictor of histologic subtypes linked to recurrence in basal cell carcinoma of the skin.

AbstractBACKGROUND:
Basal cell carcinoma (BCC) recurrences, especially in the facial region, represent a complex cosmetic problem. To date the possibility of predicting recurrence is supported solely by the histologic subtype.
OBJECTIVE:
To evaluate the relationship between BCC histologic subtypes linked to high and low risk of recurrence and the presence of hyperechoic spots on sonography.
METHODS:
Retrospective analysis of the pre-surgical ultrasound examinations of primary BCC tumours with visualization and counting of intra-tumoural hyperechoic spots. The data were then correlated with the corresponding histologic subtype.
RESULTS:
Thirty one patients with histologically proven BCC were included in the study. Hyperechoic spots were detected in all cases and there was a positive, statistically significant association between hyperechoic spots count and high recurrence risk histologic subtypes. Higher hyperechoic spots count was found in the recurrence-prone micronodular, sclerosing variant and morpheiform BCC subtypes. Low risk and high risk of recurrence showed a significant difference on the mean hyperechoic spots count of 5.5 (range: 3-25) and 8 (4-81). A cut-off point ≥7 hyperechoic spots presented a sensitivity of 79% and specificity of 53% for predicting the high risk of recurrence subtypes.
CONCLUSION:
The presence and count of hyperechoic spots within BCC lesions may help predicting the high risk of recurrence histologic subtypes.
AuthorsX Wortsman, P Vergara, A Castro, D Saavedra, F Bobadilla, I Sazunic, V Zemelman, J Wortsman
JournalJournal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 29 Issue 4 Pg. 702-7 (Apr 2015) ISSN: 1468-3083 [Electronic] England
PMID25200424 (Publication Type: Journal Article)
Copyright© 2014 European Academy of Dermatology and Venereology.
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Basal Cell (diagnostic imaging, pathology)
  • Facial Neoplasms (diagnostic imaging, pathology)
  • Female
  • Head and Neck Neoplasms (diagnostic imaging, pathology)
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Factors
  • Scalp
  • Skin Neoplasms (diagnostic imaging, pathology)
  • Ultrasonography

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