Abstract | DEFINITION: LACUNA IN KNOWLEDGE: No useful specific test for autoimmunity affecting the inner ear exists. OBJECTIVE OF STUDY: To gather evidence regarding cochlin in AIED. METHODOLOGY: Systematic review of human studies and animal experimental studies on inner ear antigens was undertaken. SEARCH STRATEGY: We searched MEDLINE (1965-2012), and Pubmed for relevant studies. A combination of key words for inner ear, autoimmunity (autoimmune, immune mediated) and cochlin were used. RESULTS: A number of antigens have been implicated in autoimmune inner ear disease. Cochlin is a major component of the extracellular matrix in the inner ear and a promising candidate. We present evidence in literature on the role of this protein in the pathogenesis of autoimmune inner ear disease.
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Authors | Paramita Baruah |
Journal | Auris, nasus, larynx
(Auris Nasus Larynx)
Vol. 41
Issue 6
Pg. 499-501
(Dec 2014)
ISSN: 1879-1476 [Electronic] Netherlands |
PMID | 25199741
(Publication Type: Journal Article, Review, Systematic Review)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Autoantigens
- COCH protein, human
- Coch protein, mouse
- Extracellular Matrix Proteins
- Immunosuppressive Agents
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Topics |
- Animals
- Autoantigens
(immunology)
- Autoimmune Diseases
(drug therapy, immunology)
- Extracellular Matrix
(immunology)
- Extracellular Matrix Proteins
(immunology)
- Hearing Loss, Sensorineural
(drug therapy, immunology)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Labyrinth Diseases
(drug therapy, immunology)
- Mice
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