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Differential clastogenic sensitivity of heterochromatin and euchromatin: evidence from an in vivo study made on a submammalian vertebrate.

Abstract
One of the properties often attributed to heterochromatin is its susceptibility to induced aberrations and exchanges. However, earlier studies made mostly on different mammalian in vitro cell lines on the distribution of aberrations within euchromatin and heterochromatin at metaphase chromosome level have given contradictory results. In the present study, an attempt has been made to evaluate the clastogenic sensitivity of heterochromatin and euchromatin using somatic chromosome complements of a submammalian vertebrate as experimental model and considering both chromosome aberrations and SCEs as end points.
AuthorsS N Banerjee, S Chakrabarti
JournalIn vivo (Athens, Greece) (In Vivo) 1989 Jan-Feb Vol. 3 Issue 1 Pg. 55-60 ISSN: 0258-851X [Print] Greece
PMID2519833 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Chromatin
  • Heterochromatin
Topics
  • Animals
  • Bone Marrow Cells
  • Bufonidae
  • Chromatin (physiology, radiation effects, ultrastructure)
  • Chromosome Aberrations
  • Chromosome Banding
  • Chromosome Mapping
  • Female
  • Heterochromatin (physiology, radiation effects, ultrastructure)
  • Karyotyping
  • Male
  • Metaphase
  • Mutagenesis
  • Whole-Body Irradiation

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