HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Epigallocatechin-3-gallate protects against cisplatin nephrotoxicity by inhibiting the apoptosis in mouse.

Abstract
Cisplatin (CP) is a commonly used anticancer drug, but its notable side effect of nephrotoxicity limits its use in clinic. Epigallocatechin-3-gallate (EGCG), an anti-oxidant, anti-inflammatory, and anti-tumorigenic green tea polyphenol, has been available on the market for its beneficial effects. The aim of this study was to investigate whether EGCG can prevent the nephrotoxic effect of CP and the involved mechanisms. Male C57/BL6 mice were randomly divided into four groups: control group, EGCG group, CP group, and CP+EGCG group. On day 5, mice were sacrificed. Our results showed that EGCG treatment significantly ameliorated the histopathological changes and the increased serum creatinine and blood urea nitrogen (BUN) induced by CP. TUNEL-positive cells significantly reduced in the CP+EGCG group compared with CP group. EGCG also inhibited the expression of the ligand of death receptor Fas (Fas-L), apoptosis regulator BAX (Bax) and tumor-suppressor protein p53, and increased the expression of B-cell lymphoma 2 (Bcl-2). These findings suggest that EGCG can ameliorate CP-induced apoptosis in the kidney by regulating death receptor Fas conducted extrinsic pathway, and the expression of Bax and Bcl-2.
AuthorsPeimei Zou, Jian Song, Bei Jiang, Fei Pei, Binbin Chen, Xiangdong Yang, Guangyi Liu, Zhao Hu
JournalInternational journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 7 Issue 8 Pg. 4607-16 ( 2014) ISSN: 1936-2625 [Electronic] United States
PMID25197333 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Antioxidants
  • Catechin
  • epigallocatechin gallate
  • Cisplatin
Topics
  • Animals
  • Antineoplastic Agents (toxicity)
  • Antioxidants (pharmacology)
  • Apoptosis (drug effects)
  • Catechin (analogs & derivatives, pharmacology)
  • Cisplatin (toxicity)
  • Disease Models, Animal
  • Kidney (drug effects, pathology)
  • Kidney Diseases (chemically induced, pathology, prevention & control)
  • Male
  • Mice
  • Mice, Inbred C57BL

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: