Abstract | PURPOSE: MATERIALS AND METHODS: We searched the Cochrane Controlled Trials Register, clinicaltrials.gov, MEDLINE(®), EMBASE(®), Google Scholar and recently presented meeting abstracts for reports in any language. Bibliographies of included studies were then hand searched for any missed articles. The study protocol was prospectively registered at PROSPERO (No. CRD42014009639). Reports were assessed and data abstracted in duplicate, with differences resolved by consensus. Risk of bias was assessed using standardized instruments. RESULTS: We identified 1,547 studies, of which 8 are included in the meta-analysis. Pooled results demonstrated that continuous antibiotic prophylaxis significantly reduced the risk of recurrent febrile or symptomatic urinary tract infection (pooled OR 0.63, 95% CI 0.42-0.96) but, if urinary tract infection occurred, increased the risk of antibiotic resistant organism (pooled OR 8.75, 95% CI 3.52-21.73). A decrease in new renal scarring was not associated with continuous antibiotic prophylaxis use. Adverse events were similar between the 2 groups. Significant heterogeneity existed between studies (I(2) 50%, p = 0.03), specifically between those trials with significant risk of bias (eg unclear protocol descriptions and/or lack of blinding). CONCLUSIONS:
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Authors | Hsin-Hsiao S Wang, Rasheed A Gbadegesin, John W Foreman, Shashi K Nagaraj, Delbert R Wigfall, John S Wiener, Jonathan C Routh |
Journal | The Journal of urology
(J Urol)
Vol. 193
Issue 3
Pg. 963-9
(Mar 2015)
ISSN: 1527-3792 [Electronic] United States |
PMID | 25196653
(Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Review, Systematic Review)
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Copyright | Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Topics |
- Antibiotic Prophylaxis
- Humans
- Urinary Tract Infections
(etiology, prevention & control)
- Vesico-Ureteral Reflux
(complications)
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