Abstract |
Giant cell arteritis (GCA) has been previously associated with cranial mononeuritis (usually optic neuritis). We hereby describe a 68-year-old man who presented due to fever and diplopia of acute onset. Physical examination revealed left abducens nerve palsy and a hearing defect in the right ear. Brain imaging and cerebrospinal fluid analysis were not diagnostic. GCA was suspected, and treatment with high-dose methylprednisolone was initiated, leading to marked improvement. Temporal artery biopsy confirmed the presence of GCA. While considering corticosteroid tapering, the patient experienced hoarseness due to right laryngeal nerve palsy. Addition of cyclophosphamide to the treatment resulted in full response. GCA mainly affects large vessels, but one or more cranial nerve palsies may also occur. Following a review of the literature, this is the first report of three cranial nerve palsies in the setting of histologically proven GCA. The role of cyclophosphamide in this entity is also discussed.
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Authors | Christina Fytili, Vassiliki Kalliopi Bournia, Chryssa Korkou, Georgios Pentazos, Alexander Kokkinos |
Journal | Rheumatology international
(Rheumatol Int)
Vol. 35
Issue 4
Pg. 773-6
(Apr 2015)
ISSN: 1437-160X [Electronic] Germany |
PMID | 25194431
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Immunosuppressive Agents
- Cyclophosphamide
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Topics |
- Aged
- Cranial Nerve Diseases
(complications, drug therapy, pathology)
- Cyclophosphamide
(therapeutic use)
- Giant Cell Arteritis
(complications, drug therapy, pathology)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Treatment Outcome
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