No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.

Abstract

BACKGROUND:

Calcium intake may reduce risk of colorectal cancer, but the mechanisms remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related pathways have yielded inconsistent results.

METHODS:

To identify gene-calcium interactions, we tested interactions between approximately 2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 colorectal cancer cases and 9,503 controls of European ancestry. To test for multiplicative interactions, we used multivariable logistic regression and defined statistical significance using the conventional genome-wide α = 5E-08.

RESULTS:

After accounting for multiple comparisons, there were no statistically significant SNP interactions with total, dietary, or supplemental calcium intake.

CONCLUSIONS:

We found no evidence of SNP interactions with calcium intake for colorectal cancer risk in a large population of 18,509 individuals.

IMPACT:

These results suggest that in genome-wide analysis common genetic variants do not strongly modify the association between calcium intake and colorectal cancer in European populations.

• Authors: Mengmeng Du, Xuehong Zhang, Michael Hoffmeister, Robert E Schoen, John A Baron, Sonja I Berndt, Hermann Brenner, Christopher S Carlson, Graham Casey, Andrew T Chan, Keith R Curtis, David Duggan, W James Gauderman, Edward L Giovannucci, Jian Gong, Tabitha A Harrison, Richard B Hayes, Brian E Henderson, John L Hopper, Li Hsu, Thomas J Hudson, Carolyn M Hutter, Mark A Jenkins, Shuo Jiao, Jonathan M Kocarnik, Laurence N Kolonel, Loic Le Marchand, Yi Lin, Polly A Newcomb, Anja Rudolph, Daniela Seminara, Mark D Thornquist, Cornelia M Ulrich, Emily White, Kana Wu, Brent W Zanke, Peter T Campbell, Martha L Slattery, Ulrike Peters, Jenny Chang-Claude, John D Potter, Colon Cancer Family Registry and Genetics and Epidemiology of Colorectal Cancer Consortium
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 23 Issue 12 Pg. 2971-6 (Dec 2014) ISSN: 1538-7755 [Electronic] United States
• PMID: 25192705 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: ©2014 American Association for Cancer Research.

Chemical References

• Calcium, Dietary

Topics

• Calcium, Dietary (therapeutic use)
• Colorectal Neoplasms (epidemiology, genetics)
• Female
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Male
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors