The unexplored roles of human serum IgA.

Abstract

The roles of human serum IgA, in contrast to that of mucosal IgA, are relatively unexplored. Previous studies have shown that IgA mediates either pro- or anti-inflammatory effects in innate immune cells. Serum IgA has been shown to interact with many proteins and glycoproteins of which the functions and mechanisms are not fully characterized. Here, we present fresh perspectives into the roles of serum IgA, describing novel IgA-protein interactions, the importance of its glycosylation status in normal functions, and the plausible role of IgA as a driver and regulator of autoimmune diseases/immune overactivation. Other potential roles, including the regulation of cytokines, effector cell function, and homeostasis, are considered in view of the maintenance of immune function. We anticipate future research to uncover new anti-inflammatory or pro-inflammatory roles of human serum IgA in immune functions and dysfunctions, with implications on systemic lupus erythematosus (SLE).

• Authors: Ka Wai Leong, Jeak Ling Ding
• Journal: DNA and cell biology (DNA Cell Biol) Vol. 33 Issue 12 Pg. 823-9 (Dec 2014) ISSN: 1557-7430 [Electronic] United States
• PMID: 25188736 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin A

Topics

• Adaptive Immunity
• Animals
• Glycosylation
• Humans
• Immunoglobulin A (blood, physiology)
• Intestinal Mucosa (immunology)
• Leukocytes (immunology)
• Lupus Erythematosus, Systemic (blood, immunology)
• Protein Binding
• Protein Processing, Post-Translational