Peptides and peptidomimetics as immunomodulators.

Abstract

Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides, synthesis and modified amino acid side chains have contributed to the development of a new generation of therapeutic agents for autoimmune diseases and cancer. The design of peptides/peptidomimetics for immunomodulation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, systemic lupus and HIV infection is reviewed. In cancer therapy, peptide epitopes are used in such a way that the body is trained to recognize and fight the cancer cells locally as well as systemically.

• Authors: Ameya S Gokhale, Seetharama Satyanarayanajois
• Journal: Immunotherapy (Immunotherapy) Vol. 6 Issue 6 Pg. 755-74 ( 2014) ISSN: 1750-7448 [Electronic] England
• PMID: 25186605 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Epitopes, B-Lymphocyte
• Epitopes, T-Lymphocyte
• Immunologic Factors
• Peptides
• Peptidomimetics

Topics

• Autoimmune Diseases (drug therapy, immunology)
• Drug Design
• Epitopes, B-Lymphocyte (immunology)
• Epitopes, T-Lymphocyte (immunology)
• Humans
• Immunologic Factors (chemistry, immunology, therapeutic use)
• Neoplasms (drug therapy, immunology)
• Peptides (chemistry, immunology, therapeutic use)
• Peptidomimetics (chemistry, immunology, therapeutic use)
• Protein Conformation