[Successful eculizumab treatment for multiple coronary thrombosis complicated in paroxysmal nocturnal hemoglobinuria].

Abstract

We herein report a rare case of paroxysmal nocturnal hemoglobinuria (PNH) who repeatedly developed coronary arterial thromboembolism. Anticoagulant therapies including heparin, aspirin as an antiplatelet agent and even drug-eluting stent placement in the coronary artery failed to prevent the recurrence of ischemic heart disease. Of note, initiating the administration of a humanized anti-C5 antibody, eculizumab, achieved prompt thrombolysis and maintenance treatment with eculizumab prevented the recurrence of thromboembolic disease in this patient. Taking these observations together, we suggest that the use of eculizumab be considered for treatment or prevention of arterial thrombosis complicated by PNH, although arterial thrombosis is an extremely rare event in the Japanese population.

• Authors: Ayuko Taniguchi, Takayuki Ikezoe, Asako Takeuchi, Kazuto Togitani, Mitsuhiro Yoshimoto, Katsutoshi Tanioka, Hiroaki Kitaoka, Akihito Yokoyama
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 55 Issue 8 Pg. 965-9 (Aug 2014) ISSN: 0485-1439 [Print] Japan
• PMID: 25186487 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Anticoagulants
• eculizumab

Topics

• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Anticoagulants (therapeutic use)
• Coronary Angiography
• Coronary Thrombosis (complications, diagnosis, drug therapy)
• Hemoglobinuria, Paroxysmal (complications, diagnosis, drug therapy)
• Humans
• Male
• Middle Aged