Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with asymptomatic malaria in a rural community in Burkina Faso.

Abstract

OBJECTIVE:

To investigate 4 combinations of mutations responsible for glucose-6-phosphate dehydrogenase (G6PD) deficiency in a rural community of Burkina Faso, a malaria endemic country.

METHODS:

Two hundred individuals in a rural community were genotyped for the mutations A376G, G202A, A542T, G680T and T968C using TaqMan single nucleotide polymorphism assays and polymerase chain reaction followed by restriction fragment length polymorphism.

RESULTS:

The prevalence of the G6PD deficiency was 9.5% in the study population. It was significantly higher in men compared to women (14.3% vs 6.0%, P=0.049). The 202A/376G G6PD A- was the only deficient variant detected. Plasmodium falciparum asymptomatic parasitaemia was significantly higher among the G6PD-non-deficient persons compared to the G6PD-deficient (P<0.001). The asymptomatic parasitaemia was also significantly higher among G6PD non-deficient compared to G6PD-heterozygous females (P<0.001).

CONCLUSIONS:

This study showed that the G6PD A- variant associated with protection against asymptomatic malaria in Burkina Faso is probably the most common deficient variant.

• Authors: Abdoul Karim Ouattara, Cyrille Bisseye, Bapio Valery Jean Télesphore Elvira Bazie, Birama Diarra, Tegwindé Rebeca Compaore, Florencia Djigma, Virginio Pietra, Remy Moret, Jacques Simpore
• Journal: Asian Pacific journal of tropical biomedicine (Asian Pac J Trop Biomed) Vol. 4 Issue 8 Pg. 655-8 (Aug 2014) ISSN: 2221-1691 [Print] China
• PMID: 25183336 (Publication Type: Journal Article)