Aptamer-based cell imaging reagents capable of fluorescence switching.

Abstract	We describe an aptamer-conjugated polydiacetylene imaging probe (ACP) that shows highly specific fluorescence switching upon binding to epithelial cancer cells that overexpress the tumor biomarker protein EpCAM (epithelial cell adhesion molecule) on their surface.
Authors	Yun Kyung Jung, Min-Ah Woo, H Tom Soh, Hyun Gyu Park
Journal	Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 50 Issue 82 Pg. 12329-32 (Oct 21 2014) ISSN: 1364-548X [Electronic] England
PMID	25182171 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Antigens, Neoplasm Aptamers, Nucleotide Biomarkers, Tumor Cell Adhesion Molecules EPCAM protein, human Epithelial Cell Adhesion Molecule Fluorescent Dyes Polyacetylene Polymer Polymers Polyynes polydiacetylene
Topics	Antigens, Neoplasm (metabolism) Aptamers, Nucleotide (chemistry, pharmacology) Biomarkers, Tumor (metabolism) Cell Adhesion Molecules (metabolism) Cell Line Cell Line, Tumor Diagnostic Imaging Epithelial Cell Adhesion Molecule Fluorescence Fluorescent Dyes (chemistry, pharmacology) Humans Polyacetylene Polymer Polymers (chemistry, pharmacology) Polyynes (chemistry, pharmacology)

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