BRMS1 regulates apoptosis in non-small cell lung cancer cells.

Abstract

Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as a metastasis suppressor gene in human breast cancer. Previous studies have reported that loss of BRMS1 expression correlates with tumor progression, and poor prognosis in NSCLC. However, the role of BRMS1 in NSCLC is not fully understood. In this study, we found that expression of BRMS1 in A549 cells did not affect cell growth under normal culture conditions but sensitized cells to apoptosis induced by serum deprivation. Consistently, knockdown of endogenous BRMS1 expression in H1299 cells suppressed cell apoptosis. We identified that BRMS1 regulate apoptosis in NSCLC cells by modulating Stat3 activation. Taken together, our results show that BRMS1 sensitizes NSCLC cells to apoptosis through Stat3 signaling pathway, suggesting a potential role of BRMS1 in regulating NSCLC apoptosis and metastasis.

• Authors: Jijun You, Xuejun He, Haibing Ding, Tingrong Zhang
• Journal: Cell biochemistry and biophysics (Cell Biochem Biophys) Vol. 71 Issue 1 Pg. 465-72 (Jan 2015) ISSN: 1559-0283 [Electronic] United States
• PMID: 25182004 (Publication Type: Journal Article)

Chemical References

• BRMS1 protein, human
• Interleukin-6
• Repressor Proteins
• STAT3 Transcription Factor

Topics

• Apoptosis (genetics)
• Carcinoma, Non-Small-Cell Lung (pathology)
• Cell Line, Tumor
• Cell Proliferation (genetics)
• Gene Expression Regulation, Neoplastic
• Gene Knockdown Techniques
• Humans
• Interleukin-6 (metabolism)
• Lung Neoplasms (pathology)
• Neoplasm Metastasis
• Repressor Proteins (deficiency, genetics, metabolism)
• STAT3 Transcription Factor (metabolism)
• Signal Transduction (genetics)