Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia.

Abstract

In the present study, effects of the serotonergic system of the dorsal hippocampus (CA1) on harmaline-induced amnesia were examined. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-peritoneal (i.p.) administration of harmaline (1mg/kg) induced impairment of memory retention. Moreover, intra-CA1 administration of 5-HT1B/1D receptor agonist, CP94253 (5 ng/mouse), 5-HT1B/1D receptor antagonist, GR127935 (0.05 and 0.5 ng/mouse), 5-HT2A/2B/2C receptor agonist, α-methyl 5-HT (0.5 ng/mouse) and 5-HT2 receptor antagonist, cinancerine (0.5 ng/mouse) impaired memory acquisition, but did not affect locomotor activity and tail flick. Furthermore, pre-training intra-CA1 injection of subthreshold dose of CP94253 (0.05 ng/mouse) or GR127935 (0.005 ng/mouse) reversed impairment of memory acquisition induced by harmaline (1 mg/kg, i.p.). However, pre-training intra-CA1 infusion of subthreshold dose of α-methyl 5-HT (0.005 ng/mouse) or cinancerine (0.005 ng/mouse) with the administration of harmaline (0.5 and 1 mg/kg, i.p.) heighten impairment of memory acquisition. These findings implicate the involvement of CA1 serotonergic mechanism in harmaline-induced impairment of memory acquisition.

• Authors: Mohammad Nasehi, Mehdi Jamshidi-Mehr, Fatemeh Khakpai, Mohammad-Reza Zarrindast
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 125 Pg. 70-77 (Oct 2014) ISSN: 1873-5177 [Electronic] United States
• PMID: 25181578 (Publication Type: Journal Article)
• Copyright: Copyright © 2014. Published by Elsevier Inc.

Chemical References

• CP 94253
• Central Nervous System Stimulants
• Oxadiazoles
• Piperazines
• Pyridines
• Receptor, Serotonin, 5-HT1B
• Receptor, Serotonin, 5-HT1D
• Receptor, Serotonin, 5-HT2A
• Receptor, Serotonin, 5-HT2B
• Receptor, Serotonin, 5-HT2C
• Serotonin 5-HT1 Receptor Agonists
• Serotonin 5-HT1 Receptor Antagonists
• alpha-methylserotonin
• GR 127935
• Serotonin
• Harmaline
• Cinanserin

Topics

• Amnesia (chemically induced)
• Animals
• CA1 Region, Hippocampal (drug effects, physiology)
• Central Nervous System Stimulants (pharmacology)
• Cinanserin (pharmacology)
• Harmaline (pharmacology)
• Male
• Memory (drug effects)
• Mice, Inbred Strains
• Oxadiazoles (pharmacology)
• Piperazines (pharmacology)
• Pyridines (pharmacology)
• Receptor, Serotonin, 5-HT1B (drug effects, physiology)
• Receptor, Serotonin, 5-HT1D (drug effects, physiology)
• Receptor, Serotonin, 5-HT2A (drug effects, physiology)
• Receptor, Serotonin, 5-HT2B (drug effects, physiology)
• Receptor, Serotonin, 5-HT2C (drug effects, physiology)
• Serotonin (analogs & derivatives, pharmacology)
• Serotonin 5-HT1 Receptor Agonists (pharmacology)
• Serotonin 5-HT1 Receptor Antagonists (pharmacology)