[Botulinum toxin type A (dysport) in the complex rehabilitation of children with spastic forms of cerebral palsy].

Abstract

OBJECTIVE:

To analyze the efficacy of repeated use of dysport in children with spastic forms of cerebral palsy (CP).

MATERIAL AND METHODS:

Forty-five children with CP (main group) received 8 consecutive injections of dysport in the complex treatment. A comparison group consisted of 41 children with CP who received the same complex treatment but without dysport. Disport was used intramuscular in mean dose 26±4 u/kg.

RESULTS AND CONCLUSION:

A significant decrease of the muscle tone was observed after each following injection of dysport. The muscle tone did not return to baseline 24 weeks after each following injection and significantly differed after the first 4 injections. After 8 repeated courses of botulinotherapy, a number of children needed the operative treatment, were significantly greater in the comparison group (71% vs 47%, p=0,041).

• Authors: V A Zmanovskaia, E V Levitina, D A Popkov, M N Butorina, O L Pavlova
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 114 Issue 7 Pg. 33-6 ( 2014) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 25176264 (Publication Type: English Abstract, Journal Article, Observational Study)

Chemical References

• Botulinum Toxins, Type A
• abobotulinumtoxinA

Topics

• Adolescent
• Botulinum Toxins, Type A (administration & dosage)
• Cerebral Palsy (rehabilitation)
• Child
• Child, Preschool
• Female
• Humans
• Injections, Intramuscular
• Muscle Spasticity (rehabilitation)
• Muscle Tonus (drug effects)
• Treatment Outcome