Scinderin is a Ca2+‑dependent filamentous actin (F‑actin) severing and capping
protein, which has a key role in regulated secretion. However, little is known regarding the function and mechanism of
scinderin in human
carcinoma development and progression. In the present study, the
biological function of
scinderin was investigated using a cell proliferation assay, flow cytometric analysis and a Transwell assay in highly tumorigenic and the metastatic human
gastric cancer cell line SGC‑7901 transfected with scinderin‑small hairpin
RNA lentivirus. The changes in the expression of epithelial‑mesenchymal transition (EMT) markers were also investigated. The results indicated that
scinderin knockdown effectively suppressed proliferation, reduced migration and arrested the cell cycle of the SGC‑7901 cells at G2/M phase. Furthermore,
scinderin knockdown altered the expression of EMT markers; the expression of E‑cadherin was significantly upregulated, along with an evident decrease in N‑cadherin and β‑catenin expression. In conclusion, the present study suggested that suppression of
scinderin impaired proliferation and migration of
gastric cancer SGC‑7901 cells and attenuates its EMT process.
Scinderin may therefore be a potential target for
tumor EMT and
therapy against
gastric cancer.