[Renal cortex ischemia, right atrial thrombosis and coronary occlusion in anti-phospholipid antibody syndrome].

Abstract

The presence of a lupus anticoagulant (LA) is paradoxically associated with a high incidence of arterial and venous thrombosis. In a patient with a lupus-like systemic disease, having received phenindione for 11 years, LA was discovered in association with recurrent deep venous thrombosis, a right atrial thrombus, coronary occlusion, arterial hypertension, thrombopenia, and anticardiolipin antibodies without anti-DNA antibodies. Renal cortical ischemia was detected by a tomographic scan. Renal biopsy showed glomerular ischemia and diffuse interstitial fibrosis. After a one-year anticoagulant and steroid therapy, LA has disappeared despite a high level of anticardiolipin antibodies, and renal function remains normal.

• Authors: M Ramdane, R Gryman, O Bacques, P Callard, D Kleinknecht
• Journal: Nephrologie (Nephrologie) Vol. 10 Issue 4 Pg. 189-93 ( 1989) ISSN: 0250-4960 [Print] Switzerland
• Vernacular Title: Ischémie rénale corticale, thrombose auriculaire droite et occlusion coronaire au cours d'un syndrome des anticorps antiphospholipides.
• PMID: 2517317 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Blood Coagulation Factors
• Cardiolipins
• Lupus Coagulation Inhibitor

Topics

• Autoantibodies (analysis, immunology)
• Autoimmune Diseases (complications, immunology)
• Blood Coagulation Factors (analysis, immunology)
• Cardiolipins (immunology)
• Coronary Disease (etiology)
• Heart Atria
• Heart Diseases (etiology)
• Humans
• Ischemia (etiology)
• Kidney Cortex (blood supply, pathology)
• Lupus Coagulation Inhibitor
• Male
• Middle Aged
• Thrombophlebitis (etiology)
• Thrombosis (etiology)