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Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL/6 mice.

Abstract
Chlorogenic acid (CHA) is an antioxidant polyphenol prevalent in human diet, with coffee, fruits, and vegetables being its main source. Effects of CHA and CHA metabolites were evaluated on the IL-8 production in human intestinal Caco-2 cells induced by combined stimulation with tumour necrosis factor alpha (TNFα) and H2O2. CHA and caffeic acid (CA) inhibited TNFα- and H2O2-induced IL-8 production. We also examined the in vivo effects of CHA and CA using dextran sulphate sodium (DSS)-induced colitis in mice. CHA attenuated DSS-induced body weight loss, diarrhea, fecal blood, and shortening of colon and dramatically improved colitis histological scores. Furthermore, increases in the mRNA expression of colonic macrophage inflammatory protein 2 and IL-1β, which were induced by DSS, were significantly suppressed by CHA supplementation. These results suggest that dietary CHA use may aid in the prevention of intestinal inflammatory conditions.
AuthorsHee Soon Shin, Hideo Satsu, Min-Jung Bae, Zhaohui Zhao, Haru Ogiwara, Mamoru Totsuka, Makoto Shimizu
JournalFood chemistry (Food Chem) Vol. 168 Pg. 167-75 (Feb 01 2015) ISSN: 1873-7072 [Electronic] England
PMID25172696 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Interleukin-1beta
  • Interleukin-8
  • Tumor Necrosis Factor-alpha
  • Chlorogenic Acid
  • Dextran Sulfate
Topics
  • Animals
  • Anti-Inflammatory Agents (administration & dosage, pharmacology)
  • Caco-2 Cells
  • Chlorogenic Acid (administration & dosage, pharmacology)
  • Colitis (chemically induced, drug therapy, immunology)
  • Dextran Sulfate (adverse effects)
  • Female
  • Humans
  • Interleukin-1beta (immunology)
  • Interleukin-8 (immunology)
  • Intestines (drug effects, immunology)
  • Mice
  • Mice, Inbred C57BL
  • Tumor Necrosis Factor-alpha (immunology)

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