Abstract | RATIONALE AND OBJECTIVES: To evaluate neurochemical alterations in Heschl's gyri and determine the most affected side in case of unilateral acoustic neuroma using magnetic resonance spectroscopy (MRS). MATERIALS AND METHODS: Fifteen patients with unilateral acoustic neuroma were studied. Following routine cranial MRI sequences, MRS of Heschl's gyri on tumor and nontumor sides was obtained. MRS metabolite values of both Heschl's gyri were statistically compared. RESULTS: The values of N-acetylaspartate (NAA) and Cr on nontumor side Heschl's gyrus (HG) were significantly lower than that on tumor side. CONCLUSIONS: We found nontumor side HG more affected with lower NAA and Cr values, suggesting neuronal damage and decreased energy metabolism compared to the tumoral side.
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Authors | Rukiye Kilicarslan, Alpay Alkan, Ayse Aralasmak, Fadlullah Aksoy, Huseyin Toprak, Huseyin Yetis, Orhan Ozturan |
Journal | Academic radiology
(Acad Radiol)
Vol. 21
Issue 12
Pg. 1501-5
(Dec 2014)
ISSN: 1878-4046 [Electronic] United States |
PMID | 25172413
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Aspartic Acid
- N-acetylaspartate
- Creatine
- Choline
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Topics |
- Aspartic Acid
(analogs & derivatives, metabolism)
- Auditory Cortex
(anatomy & histology, metabolism)
- Biomarkers
(metabolism)
- Choline
(metabolism)
- Creatine
(metabolism)
- Female
- Humans
- Magnetic Resonance Spectroscopy
(methods)
- Male
- Middle Aged
- Neuroma, Acoustic
(metabolism)
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