Abstract | PURPOSE: To describe the structural characteristics of retinal angiomatous proliferation and chorioretinal anastomosis in childhood Coats disease and redefine the previously described macular fibrosis. METHODS: Prospective observational case series of consecutive patients with Coats disease examined over a 1-year study period. Multimodal imaging, including color fundus photography, wide-field fluorescein angiography, and spectral domain optical coherence tomography, was used to identify the features of macular retinal angiomatous proliferation and chorioretinal anastomosis. RESULTS:
Retinal angiomatous proliferation and chorioretinal anastomosis were present in 5 of 21 patients with Coats disease (24%). The lesions appeared as well demarcated, nodular retinal pigment epithelial detachments surrounded by exudate, with retinal vessels continuous with the underlying choroidal neovascularization. CONCLUSION:
Retinal angiomatous proliferation and chorioretinal anastomoses are features observed in a number of children (24% in the present series) with Coats disease and macular involvement. This lesion represents a distinct macular variant of Coats disease that underlies at least a proportion (all in the present series) of the previously described "macular fibrosis" and "subretinal mounds."
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Authors | Eric J Sigler, Jorge I Calzada |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 35
Issue 3
Pg. 537-46
(Mar 2015)
ISSN: 1539-2864 [Electronic] United States |
PMID | 25170864
(Publication Type: Case Reports, Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Antibodies, Monoclonal, Humanized
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Bevacizumab
|
Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Arterio-Arterial Fistula
(diagnosis, therapy)
- Bevacizumab
- Child
- Child, Preschool
- Choroidal Neovascularization
(diagnosis)
- Combined Modality Therapy
- Female
- Fibrosis
- Fluorescein Angiography
- Humans
- Intravitreal Injections
- Laser Coagulation
- Macula Lutea
(pathology)
- Male
- Multimodal Imaging
- Photography
- Prospective Studies
- Retinal Artery
(pathology)
- Retinal Neovascularization
(diagnosis, therapy)
- Retinal Pigment Epithelium
(pathology)
- Retinal Telangiectasis
(diagnosis, therapy)
- Tomography, Optical Coherence
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Young Adult
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