Abstract | AIM: METHODS: Two hundred and ninety-four end-stage renal disease patients participated in the study, including 182 HD and 112 PD patients. Dimension scores were calculated from a modified gastrointestinal symptom rating scale (GSRS) 18-item questionnaire, including items concerning eating dysfunction, and were used for measuring GI symptoms. Information on patient age, condition contributing to end-stage renal disease and the most recent dialysis adequacy assessment (serum Kt/V urea value) was obtained from the follow-up database and by interviewing patients and/or reviewing the medical records. Differences between the HD and PD groups were evaluated using Student's t, Pearson's χ(2) or Fisher's exact tests. RESULTS: The overall prevalence of GI symptoms, defined by a GSRS > 1, in end-stage renal disease patients was 70.7% (208/294), which differed between HD and PD patients (76.4% vs 61.6%, P < 0.01). HD patients had a higher prevalence of constipation, abdominal pain and diarrhea compared to PD patients (36.3% vs 17.9%, 32.4% vs 5.4%, 17.6% vs 4.5%, respectively, P < 0.05). PD patients had a higher prevalence of reflux compared to HD patients (32.1% vs 24.2%, P < 0.05). Additionally, reflux and eating dysfunction were more severe in PD patients (GSRS: 1.71 ± 1.15 vs 1.30 ± 0.67, 1.57 ± 0.84 vs 1.39 ± 0.61, respectively, P < 0.05), whereas HD patients had greater abdominal pain, diarrhea and constipation (GSRS: 1.22 ± 0.39 vs 1.04 ± 0.19, 1.19 ± 0.53 vs 1.07 ± 0.35, 1.51 ± 0.83 vs 1.23 ± 0.58, respectively, P < 0.05). Finally, 14.8% (27/182) of HD patients presented with more than three GI symptoms, compared to 7.2% (8/112) of PD patients (P < 0.01). CONCLUSION: HD and PD patients differ in prevalence, severity and diversity of GI symptoms.
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Authors | Rui Dong, Zhi-Yong Guo, Jia-Rong Ding, Yang-Yang Zhou, Hao Wu |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 20
Issue 32
Pg. 11370-5
(Aug 28 2014)
ISSN: 2219-2840 [Electronic] United States |
PMID | 25170224
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adult
- Aged
- Chi-Square Distribution
- China
(epidemiology)
- Female
- Gastrointestinal Diseases
(diagnosis, epidemiology)
- Humans
- Kidney Failure, Chronic
(diagnosis, epidemiology, therapy)
- Male
- Middle Aged
- Peritoneal Dialysis
(adverse effects)
- Prevalence
- Renal Dialysis
(adverse effects)
- Retrospective Studies
- Risk Factors
- Severity of Illness Index
- Surveys and Questionnaires
- Treatment Outcome
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