Efficacy and safety of bevacizumab in Chinese patients with metastatic colorectal cancer.

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of bevacizumab in the treatment of patients with metastatic colorectal cancer (mCRC).

METHODS:

In a single-center, observational study of 91 Chinese patients with mCRC who received bevacizumab in combination with chemotherapy was conducted. OBJECTIVE response rates (ORRs), progression-free survival (PFS), overall survival (OS) and adverse events were recorded, and the relationships between various clinical factors and PFS or OS were evaluated by Cox proportional hazards models.

RESULTS:

Treatment with bevacizumab and chemotherapy was effective and tolerable. Univariate analysis showed that PFS and OS were significantly associated with the Eastern Cooperative Oncology Group performance status (ECOG- PS) score, duration of bevacizumab exposure, and whether chemotherapy was continued after discontinuation of bevacizumab treatment. A multivariate analysis showed that the duration of bevacizumab exposure and whether chemotherapy was continued after discontinuation of bevacizumab were independent prognostic factors for PFS and OS.

CONCLUSION:

In Chinese mCRC population, the shorter the duration of exposure to bevacizumab and chemotherapy, the worse the prognosis is.

• Authors: Li-Ming Zhu, Ya-Zhen Zhao, Hai-Xing Ju, Lu-Ying Liu, Lei Chen, Bi-Xia Liu, Qi Xu, Cong Luo, Jie-Er Ying, Yun-Shan Yang, Hai-Jun Zhong
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 16 Pg. 6559-64 ( 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 25169487 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal, Humanized
• Organoplatinum Compounds
• Bevacizumab
• Leucovorin
• Fluorouracil
• Camptothecin

Topics

• Adult
• Aged
• Angiogenesis Inhibitors (adverse effects, therapeutic use)
• Antibodies, Monoclonal, Humanized (adverse effects, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Bevacizumab
• Camptothecin (adverse effects, analogs & derivatives, therapeutic use)
• China
• Colorectal Neoplasms (drug therapy, mortality)
• Disease-Free Survival
• Female
• Fluorouracil (adverse effects, therapeutic use)
• Humans
• Leucovorin (adverse effects, therapeutic use)
• Male
• Middle Aged
• Organoplatinum Compounds (adverse effects, therapeutic use)
• Treatment Outcome
• Young Adult