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A novel deletion mutation in RS1 gene caused X-linked juvenile retinoschisis in a Chinese family.

AbstractPURPOSE:
X-linked juvenile retinoschisis (XLRS), a leading cause of juvenile macular degeneration, is characterized by a spoke-wheel pattern in the macular region of the retina and splitting of the neurosensory retina. This study aimed to identify the underlying genetic defect in a Chinese family with XLRS.
METHODS:
The proband underwent complete ophthalmic examinations, including fundus examination, fundus autofluorescence, and optical coherence tomography. DNA extracted from proband and his younger brother was screened for mutations in RS1 gene. The detected RS1 mutation was tested in all available family members and 200 healthy controls.
RESULTS:
Reduced visual acuity, spoke-wheel pattern at the fovea, and split retina were observed in the proband. A novel frameshift mutation c.206-207delTG in the RS1 gene, leading to a truncated protein (p.L69fs16X), was identified in the proband and his younger brother. This mutation was not found in any unaffected member or in the healthy controls. The mother of the proband was hemizygous for this mutant allele.
CONCLUSIONS:
We identified a novel causative mutation of RS1 in a Chinese family with XLRS. This finding expands the mutation spectrum of RS1 and provides evidence for a phenotype-genotype study in XLRS.
AuthorsY Huang, L Mei, B Gui, W Su, D Liang, L Wu, Q Pan
JournalEye (London, England) (Eye (Lond)) Vol. 28 Issue 11 Pg. 1364-9 (Nov 2014) ISSN: 1476-5454 [Electronic] England
PMID25168411 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Eye Proteins
  • RS1 protein, human
Topics
  • Asian People (genetics)
  • Base Sequence
  • Child
  • China
  • DNA Mutational Analysis
  • Eye Proteins (genetics)
  • Fluorescein Angiography
  • Frameshift Mutation
  • Humans
  • Infant
  • Male
  • Pedigree
  • Polymerase Chain Reaction
  • Retinoschisis (genetics)
  • Sequence Deletion
  • Tomography, Optical Coherence
  • Visual Acuity

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