Effects of drugs and fatty acids related to Reye syndrome on brain water content in rats.

Abstract

Brain water content was measured by gas-chromatography in rats following intraperitoneal injection of drugs and fatty acids related to the etiology of Reye syndrome. A statistically significant increase in brain water content was observed following injection of 5% glucose solution, valproic acid, acetyl salicylic acid, calcium hopantenate, margosa oil, 4-pentenoic acid, linolenate and arachidonate. Seizures occurred in all animals given valproic acid, margosa oil and 4-pentenoic acid, and in 25% of those given 5% glucose solution + anti-diuretic hormone. The results of these studies may help in the selection of appropriate agents for experimental induction of acute encephalopathy and brain edema in animal models of Reye syndrome.

• Authors: Y Katafuchi, I Yoshida, F Yamashita, D Sinniah
• Journal: Acta paediatrica Japonica : Overseas edition (Acta Paediatr Jpn) Vol. 31 Issue 2 Pg. 115-9 (Apr 1989) ISSN: 0374-5600 [Print] Australia
• PMID: 2516690 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fatty Acids

Topics

• Animals
• Body Water (drug effects, metabolism)
• Brain (drug effects, metabolism)
• Disease Models, Animal
• Fatty Acids (pharmacology)
• Male
• Rats
• Rats, Inbred Strains
• Reye Syndrome (etiology, metabolism)