Congenital toxoplasmosis from a mother with type 2 diabetes mellitus: a case report.

Abstract

A 33-year-old woman with type 2 diabetes mellitus (DM) was suspected of being primarily infected with Toxoplasma gondii at 12 weeks of gestation (GW). Although acetylspiramycin was started at 17 GW, the T. gondii DNA gene was detected in the amniotic fluid at 18 GW. Chemotherapy was changed to pyrimethamine plus sulfadiazine from 20 GW, but was changed back to acetylspiramycin after 2 weeks because of vomiting. Acetylspiramycin was continued until her delivery. DM was controlled well during the pregnancy. An asymptomatic male baby was born by cesarean section at 37 GW, and was treated with acetylspiramycin for 4 weeks because the polymerase chain reaction results of umbilical cord blood were positive. He has developed normally until the present, that is, 6 months of age. Herein, we describe a case report in which symptomatic congenital toxoplasmosis was avoided in a pregnant woman with an immunosuppressive risk due to prompt chemotherapy.

• Authors: Shimpei Sato, Masakazu Nishida, Kaei Nasu, Hisashi Narahara, Kazumi Norose, Fumie Aosai
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 40 Issue 11 Pg. 2158-61 (Nov 2014) ISSN: 1447-0756 [Electronic] Australia
• PMID: 25164320 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

Chemical References

• Antiprotozoal Agents
• Hypoglycemic Agents

Topics

• Adult
• Antiprotozoal Agents (adverse effects, therapeutic use)
• Diabetes Mellitus, Type 2 (complications, drug therapy, immunology)
• Drug Therapy, Combination (adverse effects)
• Female
• Humans
• Hypoglycemic Agents (therapeutic use)
• Immunocompromised Host (drug effects)
• Infant, Newborn
• Male
• Pregnancy
• Pregnancy Complications, Parasitic (drug therapy, immunology, parasitology)
• Pregnancy Trimester, Second
• Pregnancy in Diabetics (drug therapy, immunology)
• Toxoplasma (drug effects, growth & development)
• Toxoplasmosis (complications, drug therapy, immunology, parasitology)
• Toxoplasmosis, Congenital (prevention & control)
• Treatment Outcome