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Cispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure.

Abstract
A new antibiotic, cispentacin, was isolated from the culture broth of a Bacillus cereus strain, L450-B2. The antibiotic is water-soluble and amphoteric; its structure was determined by spectroscopic analysis and chemical synthesis to be (1R,2S)-2-aminocyclopentane-1-carboxylic acid. Cispentacin demonstrated only weak in vitro activity against certain fungi but strong protection of mice from lethal infection of Candida albicans A9540.
AuthorsM Konishi, M Nishio, K Saitoh, T Miyaki, T Oki, H Kawaguchi
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 42 Issue 12 Pg. 1749-55 (Dec 1989) ISSN: 0021-8820 [Print] England
PMID2516082 (Publication Type: Journal Article)
Chemical References
  • Antifungal Agents
  • Cycloleucine
  • cispentacin
Topics
  • Antifungal Agents (isolation & purification, pharmacology)
  • Bacillus cereus (analysis)
  • Candida albicans (drug effects)
  • Chemical Phenomena
  • Chemistry
  • Cycloleucine (isolation & purification, pharmacology)
  • Fermentation

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