Abstract |
A new antibiotic, cispentacin, was isolated from the culture broth of a Bacillus cereus strain, L450-B2. The antibiotic is water-soluble and amphoteric; its structure was determined by spectroscopic analysis and chemical synthesis to be (1R,2S)-2-aminocyclopentane-1-carboxylic acid. Cispentacin demonstrated only weak in vitro activity against certain fungi but strong protection of mice from lethal infection of Candida albicans A9540.
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Authors | M Konishi, M Nishio, K Saitoh, T Miyaki, T Oki, H Kawaguchi |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 42
Issue 12
Pg. 1749-55
(Dec 1989)
ISSN: 0021-8820 [Print] England |
PMID | 2516082
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Cycloleucine
- cispentacin
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Topics |
- Antifungal Agents
(isolation & purification, pharmacology)
- Bacillus cereus
(analysis)
- Candida albicans
(drug effects)
- Chemical Phenomena
- Chemistry
- Cycloleucine
(isolation & purification, pharmacology)
- Fermentation
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