Abstract | INTRODUCTION: MATERIALS AND METHODS: A total of 13 pre-term infants who received intravenous paracetamol because of contrindications or side effects to oral ibuprofen were retrospectively enrolled. In the first patient, the dose regimen was 15 mg/kg/dose, every 6 hours. As the patient developed significant elevation in transaminase levels, the dose was decreased to 10 mg/kg/dose, every 8 hours in the following 12 patients. Echocardiographic examination was conducted daily. In case of closure, it was repeated after 2 days and when needed thereafter in terms of reopening. RESULTS: A total of 13 patients received intravenous paracetamol. Median gestational age was 29 weeks ranging from 24 to 31 weeks and birth weight was 950 g ranging from 470 to 1390 g. The median postnatal age at the first intravenous paracetamol dose was 3 days ranging from 2 to 9 days. In 10 of the 13 patients (76.9%), patent ductus arteriosus was closed at the median 2nd day of intravenous paracetamol ranging from 1 to 4 days. When the patient who developed hepatotoxicity was eliminated, the closure rate was found to be 83.3% (10/12). CONCLUSION:
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Authors | Kadir Şerafettin Tekgündüz, Naci Ceviz, İbrahim Caner, Haşim Olgun, Yaşar Demirelli, Canan Yolcu, İrfan Oğuz Şahin, Mustafa Kara |
Journal | Cardiology in the young
(Cardiol Young)
Vol. 25
Issue 6
Pg. 1060-4
(Aug 2015)
ISSN: 1467-1107 [Electronic] England |
PMID | 25160728
(Publication Type: Journal Article)
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Chemical References |
- Analgesics, Non-Narcotic
- Acetaminophen
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Topics |
- Acetaminophen
(administration & dosage, adverse effects)
- Administration, Intravenous
- Analgesics, Non-Narcotic
(administration & dosage, adverse effects)
- Birth Weight
- Drug Administration Schedule
- Ductus Arteriosus, Patent
(drug therapy)
- Female
- Gestational Age
- Humans
- Infant, Newborn
- Infant, Premature
- Male
- Retrospective Studies
- Treatment Outcome
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