Enzalutamide in chemo-naïve castration-resistant prostate cancer: effective for most but not for all.

Abstract

Continued research in the treatment of castration-resistant prostate cancer (CRPC) has allowed for a clearer understanding of this disease entity and further treatment advances. In a study recently published by Beer et al. in the New England Journal of Medicine, another advance to treatment was demonstrated for the androgen receptor (AR) signaling inhibitor, enzalutamide, in patients with chemotherapy-naïve metastatic CRPC. Although a large majority of patients responded favorably to enzalutamide in the prechemotherapy setting, a small but significant proportion of patients demonstrated no meaningful benefit to this agent. This highlights an important concept in the understanding of this disease: inherent and acquired resistance to AR-targeting therapies.

• Authors: Benjamin L Maughan, Emmanuel S Antonarakis
• Journal: Asian journal of andrology (Asian J Androl) 2014 Nov-Dec Vol. 16 Issue 6 Pg. 807-8 ISSN: 1745-7262 [Electronic] China
• PMID: 25155108 (Publication Type: Journal Article, Comment)

Chemical References

• Androgen Receptor Antagonists
• Antineoplastic Agents, Hormonal
• Phenylthiohydantoin

Topics

• Adenocarcinoma (drug therapy)
• Androgen Receptor Antagonists (therapeutic use)
• Antineoplastic Agents, Hormonal (therapeutic use)
• Humans
• Male
• Phenylthiohydantoin (analogs & derivatives)
• Prostatic Neoplasms (drug therapy)