Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis.

Abstract

OBJECTIVE:

To assess the efficacy of thyroid hormone replacement therapy for nephrotic syndrome (NS) patients associated with euthyroid sick syndrome (ESS).

MATERIALS AND METHODS:

The Cochrane library, ISI, Ovid, PubMed, Chinese Biomedicine Database were searched, and reference list of relevant articles were selected. Randomized controlled trials (RCTs) or quasi-RCTs with thyroid hormone replacement on NS patients associated with ESS were included in this analysis.

RESULTS:

Six trials (329 participants) were included. Meta-analysis showed that thyroid hormone replacement therapy can significantly increase the completely remission rate [OR = 3.04, 95% confidence interval (CI): 3.04-1.88, p < 0.00001] and total response rate (OR = 4.63, 95% CI: 2.46-8.71, p < 0.00001) of NS patients associated with ESS. No side effect was observed during the follow-up period. There was no obvious publication bias in the mete-analysis studies.

CONCLUSIONS:

Thyroid hormone replacement therapy significantly increases the remission of ESS in patients with NS.

• Authors: Huixin Liu, Wenjun Yan, Gaosi Xu
• Journal: Renal failure (Ren Fail) Vol. 36 Issue 9 Pg. 1360-5 (Oct 2014) ISSN: 1525-6049 [Electronic] England
• PMID: 25154407 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Thyroid Hormones

Topics

• Euthyroid Sick Syndromes (complications, drug therapy)
• Hormone Replacement Therapy (methods)
• Humans
• Nephrotic Syndrome (complications, drug therapy)
• Thyroid Hormones (therapeutic use)
• Treatment Outcome