6-Deoxy-13-hydroxy-8,11-dione-dihydrogranaticin B, an intermediate in granaticin biosynthesis, from Streptomyces sp. CPCC 200532.

Abstract

A new granaticin analogue and its hydrolysis product were isolated from Streptomyces sp. CPCC 200532. Their structures were determined to be 6-deoxy-13-hydroxy-8,11-dione-dihydrogranaticins B (1) and A (2), respectively, by detailed analysis of spectroscopic data. Compound 1 was regarded as an intermediate in granaticin biosynthesis, as it was bioconvertable to granaticin B. Compared to granaticin B, 1 showed similar cytotoxicity against cancer cell line HCT116, but decreased cytotoxicity against cancer cell lines A549, HeLa, and HepG2. Compound 2 displayed lower cytotoxicity than 1 against all four cancer cell lines tested.

• Authors: Bingya Jiang, Shufen Li, Wei Zhao, Ting Li, Lijie Zuo, Yanni Nan, Linzhuan Wu, Hongyu Liu, Liyan Yu, Guangzhi Shan, Limin Zuo
• Journal: Journal of natural products (J Nat Prod) Vol. 77 Issue 9 Pg. 2130-3 (Sep 26 2014) ISSN: 1520-6025 [Electronic] United States
• PMID: 25153802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 6-deoxy-13-hydroxy-8,11-dione-dihydrogranaticins B
• Antineoplastic Agents
• Naphthoquinones
• dihydrogranaticin
• granaticin

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Bacillus subtilis (drug effects)
• Drug Screening Assays, Antitumor
• HCT116 Cells
• Humans
• Microbial Sensitivity Tests
• Molecular Structure
• Naphthoquinones (chemistry, isolation & purification, pharmacology)
• Streptomyces (chemistry)