Abstract | BACKGROUND: METHODS: RESULTS: Increased (p<0.01) plasma KS was observed in JIA patients before treatment. Therapy resulted in a decrease in KS level. However, plasma KS level remained higher (p<0.05) than in controls. Increased levels of TGF-β1 (p<0.01) and PDGF-BB (p<0.05) in untreated JIA patients were recorded. Clinical improvement was accompanied by significant decrease in TGF-β1 and PDGF-BB, compared with a pretreatment condition and a control group. The concentrations of proteinases were characterized by different trends of alterations. When the ADAMTS-4 level increased (p<0.01) in the blood of untreated patients, the concentration of ADAMTS-5 was found to be reduced (p<0.0001), compared with controls. JIA treatment resulted in the normalization of ADAMTS-4 level. Plasma TG concentration was decreased only in untreated patients (p<0.05). We have revealed a significant correlation between plasma KS level and ADAMTS-4, TGF-β1, TG, C-reactive protein, and erythrocyte sedimentation rate levels. CONCLUSIONS: Plasma KS level in JIA patients, reflecting the aggrecan structure, indicates that treatment that modifies inflammation simultaneously does not contribute to total regeneration of articular matrix components and signalizes the need for further treatment.
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Authors | Katarzyna Winsz-Szczotka, Katarzyna Komosińska-Vassev, Kornelia Kuźnik-Trocha, Andrzej Siwiec, Bogusław Żegleń, Krystyna Olczyk |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 53
Issue 2
Pg. 291-7
(Feb 2015)
ISSN: 1437-4331 [Electronic] Germany |
PMID | 25153398
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aggrecans
- Biomarkers
- Proteoglycans
- Proto-Oncogene Proteins c-sis
- Transforming Growth Factor beta1
- Becaplermin
- Keratan Sulfate
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Topics |
- Adolescent
- Aggrecans
(blood, metabolism)
- Arthritis, Juvenile
(blood, drug therapy, metabolism)
- Becaplermin
- Biomarkers
(blood)
- Cartilage
(metabolism)
- Child
- Female
- Humans
- Keratan Sulfate
(blood)
- Male
- Proteoglycans
(metabolism)
- Proteolysis
- Proto-Oncogene Proteins c-sis
(blood, metabolism)
- Transforming Growth Factor beta1
(blood, metabolism)
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