Abstract | AIM: METHODS: RESULTS: The combination therapy exhibited a significant beneficial effect in alleviation of colitis compared to controls. Overall changes in reduction of TNF-α (114.66 ± 18.26 vs 171.78 ± 9.48 pg/mg protein, P < 0.05), IL-1β (24.9 ± 1.07 vs 33.06 ± 2.16 pg/mg protein, P < 0.05), TBARS (0.2 ± 0.03 vs 0.49 ± 0.04 μg/mg protein, P < 0.01), MPO (15.32 ± 0.4 vs 27.24 ± 3.84 U/mg protein, P < 0.05), and elevation of FRAP (23.46 ± 1.2 vs 15.02 ± 2.37 μmol/L, P < 0.05) support the preference of the combination therapy in comparison to controls. Although the monotherapies were also effective in improvement of colitis markers, the combination therapy was much better in improvement of colon oxidative stress markers including FRAP, TBARS, and MPO. CONCLUSION: The present combination is a suitable mixture in control of experimental colitis and should be trialed in the clinical setting.
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Authors | Mahsa Moeinian, Seyedeh Farnaz Ghasemi-Niri, Shilan Mozaffari, Amir Hossein Abdolghaffari, Maryam Baeeri, Mona Navaea-Nigjeh, Mohammad Abdollahi |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 20
Issue 31
Pg. 10876-85
(Aug 21 2014)
ISSN: 2219-2840 [Electronic] United States |
PMID | 25152589
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Biomarkers
- Gastrointestinal Agents
- Inflammation Mediators
- Butyric Acid
- Trinitrobenzenesulfonic Acid
- Carnitine
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Biomarkers
(metabolism)
- Butyric Acid
(pharmacology)
- Carnitine
(pharmacology)
- Colitis
(chemically induced, metabolism, microbiology, pathology, therapy)
- Colon
(drug effects, metabolism, microbiology, pathology)
- Combined Modality Therapy
- Disease Models, Animal
- Gastrointestinal Agents
(pharmacology)
- Inflammation Mediators
(metabolism)
- Lacticaseibacillus casei
(physiology)
- Male
- Oxidative Stress
(drug effects)
- Probiotics
(pharmacology)
- Rats, Wistar
- Time Factors
- Trinitrobenzenesulfonic Acid
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