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Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.

Abstract
The epidemiological evidence suggests a strong inverse relationship between dietary intake of cruciferous vegetables and the incidence of cancer. Among other constituents of cruciferous vegetables, isothiocyanates (ITC) are the main bioactive chemicals present. Phenethyl isothiocyanate (PEITC) is present as gluconasturtiin in many cruciferous vegetables with remarkable anti-cancer effects. PEITC is known to not only prevent the initiation phase of carcinogenesis process but also to inhibit the progression of tumorigenesis. PEITC targets multiple proteins to suppress various cancer-promoting mechanisms such as cell proliferation, progression and metastasis. Pre-clinical evidence suggests that combination of PEITC with conventional anti-cancer agents is also highly effective in improving overall efficacy. Based on accumulating evidence, PEITC appears to be a promising agent for cancer therapy and is already under clinical trials for leukemia and lung cancer. This is the first review which provides a comprehensive analysis of known targets and mechanisms along with a critical evaluation of PEITC as a future anti-cancer agent.
AuthorsParul Gupta, Stephen E Wright, Sung-Hoon Kim, Sanjay K Srivastava
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 1846 Issue 2 Pg. 405-24 (Dec 2014) ISSN: 0006-3002 [Print] Netherlands
PMID25152445 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Isothiocyanates
  • Reactive Oxygen Species
  • phenethyl isothiocyanate
Topics
  • Animals
  • Anticarcinogenic Agents (pharmacology)
  • Antineoplastic Agents (pharmacology)
  • Apoptosis (drug effects)
  • Autophagy (drug effects)
  • Brassicaceae
  • Humans
  • Isothiocyanates (pharmacology)
  • Reactive Oxygen Species (metabolism)
  • Vegetables

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