HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

An in vitro test of the efficacy of an anti-biofilm wound dressing.

Abstract
Broad-spectrum antimicrobial agents, such as silver, are increasingly being formulated into medicated wound dressings in order to control colonization of wounds by opportunistic pathogens. Medicated wound dressings have been shown in-vitro to be effective against planktonic cultures, but in-vivo bacteria are likely to be present in biofilms, which makes their control and eradication more challenging. Recently, a functional wound dressing (AQUACEL(®) Ag+ Extra™ (AAg + E)) has been developed that in addition to silver contains two agents (ethylenediaminetetraacetic acid (EDTA) and benzethonium chloride (BC)) designed to disrupt biofilms. Here, the efficacy of AAg + E is demonstrated using a biofilm model developed in an isothermal microcalorimeter. The biofilm was seen to remain viable in the presence of unmedicated dressing, silver-containing dressing or silver nitrate solution. In the presence of AAg + E, however, the biofilm was eradicated. Control experiments showed that neither EDTA nor BC alone had a bactericidal effect, which means it is the synergistic action of EDTA and BC disrupting the biofilm with silver being bactericidal that leads to the product's efficacy.
AuthorsJawal Said, Michael Walker, David Parsons, Paul Stapleton, Anthony E Beezer, Simon Gaisford
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 474 Issue 1-2 Pg. 177-81 (Oct 20 2014) ISSN: 1873-3476 [Electronic] Netherlands
PMID25151435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Benzethonium
  • Silver
  • Edetic Acid
  • Carboxymethylcellulose Sodium
Topics
  • Anti-Bacterial Agents (administration & dosage, pharmacology, therapeutic use)
  • Benzethonium (administration & dosage, pharmacology, therapeutic use)
  • Biofilms (drug effects)
  • Carboxymethylcellulose Sodium (administration & dosage, chemistry)
  • Edetic Acid (administration & dosage, pharmacology, therapeutic use)
  • Microbial Sensitivity Tests
  • Occlusive Dressings
  • Silver (administration & dosage, pharmacology, therapeutic use)
  • Staphylococcus aureus (drug effects, growth & development)
  • Wound Infection (drug therapy, prevention & control)
  • Wounds and Injuries (microbiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: