Ulcerative necrobiosis lipoidica successfully treated with photodynamic therapy: case report and literature review.

Ulcerative necrobiosis lipoidica (NL) is a rare skin condition refractory to conventional therapies. We treated a forty-four year old woman affected by widespread ulcerative NL with 6 sessions of topical ALA-PDT at two weeks intervals. At the end of the treatment a dramatic improvement of the clinical features was observed, with complete healing of cutaneous ulcers and marked reduction of erythema in all the treated areas. The mechanism of action of PDT in ulcer healing is still unknown; however, it is possible to hypothesize a combination of anti-inflammatory effect, immunomodulatory activity and keratinocytes photoactivation.
AuthorsFrancesco Borgia, Mario Vaccaro, Laura G Cantavenera, Emanuela Aragona, Serafinella P Cannavò
JournalPhotodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 11 Issue 4 Pg. 516-8 (Dec 2014) ISSN: 1873-1597 [Electronic] Netherlands
PMID25150669 (Publication Type: Case Reports, Journal Article, Review)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Photosensitizing Agents
  • Aminolevulinic Acid
  • Adult
  • Aminolevulinic Acid (therapeutic use)
  • Female
  • Humans
  • Leg Ulcer (complications, drug therapy, pathology)
  • Necrobiosis Lipoidica (drug therapy, etiology, pathology)
  • Photochemotherapy (methods)
  • Photosensitizing Agents (therapeutic use)
  • Treatment Outcome

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