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P68 RNA helicase as a molecular target for cancer therapy.

Abstract
The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and RNA helicase ability, p68 can also function as a co-activator for transcription factors such as estrogen receptor alpha, tumor suppressor p53 and beta-catenin. More than that, post-translational modification of p68 including phosphorylation, acetylation, sumoylation, and ubiquitylation can regulate the coactivation effect. Furthermore, aberrant expression of p68 in cancers highlights that p68 plays an important role for tumorgenesis and development. In this review, we briefly introduce the function and modulation of p68 in cancer cells, and put forward envisagement about future study about p68.
AuthorsTing-Yu Dai, Liu Cao, Zi-Chen Yang, Ya-Shu Li, Li Tan, Xin-Ze Ran, Chun-Meng Shi
JournalJournal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 33 Pg. 64 (Aug 24 2014) ISSN: 1756-9966 [Electronic] England
PMID25150365 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • DEAD-box RNA Helicases
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • DEAD-box RNA Helicases (antagonists & inhibitors, chemistry, metabolism)
  • Drug Design
  • Enzyme Inhibitors (therapeutic use)
  • Gene Expression Regulation, Neoplastic (drug effects)
  • Humans
  • Models, Molecular
  • Molecular Targeted Therapy
  • Neoplasms (drug therapy, enzymology, genetics, pathology)
  • Protein Conformation
  • Signal Transduction (drug effects)
  • Structure-Activity Relationship

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