Acne is a common but serious
skin disease, which affects approximately 80% adolescents and young adults in 11-30 age group. 42.5% of men and 50.9% of women continue to suffer from this disease into their twenties. Bacterial resistance is now at the alarming stage due to the irrational use of
antibiotics. Hence, search for new lead molecule/bioactive and rational delivery of the existing
drug (for better
therapeutic effect) to the site of action is the need of the hour. Plants and plant-derived products have been an integral part of health care system since time immemorial. Therefore, plants that are currently used for the treatment of
acne and those with a high potential are summarized in the present review. Most active
plant extracts, namely, P. granatum, M. alba, A. anomala, and M. aquifolium exhibit minimum inhibitory concentration (MIC) in the range of 4-50 µg/mL against P. acnes, while aromatic
oils of C. obovoides, C. natsudaidai, C. japonica, and C. nardus possess MICs 0.005-0.6 μL/mL and phytomolecules such as
rhodomyrtone, pulsaquinone, hydropulsaquinone,
honokiol,
magnolol,
xanthohumol lupulones,
chebulagic acid and
rhinacanthin-C show MIC in the range of 0.5-12.5 μg/mL. Novel
drug delivery strategies of important plant leads in the treatment of
acne have also been discussed.