Efficacy of insulin lispro in improving glycemic control in gestational diabetes.

To assess the safety and efficacy of insulin lispro in improving glycemic control in patients with gestational diabetes.
A retrospective observational study was conducted at a single center on 201 gestational women with diabetes. Subjects who received insulin lispro performed blood glucose self-monitoring and recorded the readings in the fasting state and 1 h after each meal. At each contact (in person or telephonic contact), the insulin dose was adjusted based on the readings measured. A total of 53 subjects also recorded glucose levels post-partum. Pregnancy and post-delivery glucose level and insulin requirements of these 53 patients were compared.
Analysis of glucose levels both fasting and post-prandial glucose levels revealed that after using insulin lispro, the number of episodes of post-prandial hyperglycemia (1 h plasma glucose >120 mg/dL) was minimal and so was the incidence of hypoglycemia. Hypoglycemia was defined as a blood sugar value of. There was neither any congenital abnormality except for a poorly formed pinna in the right ear of one baby nor any post-partum complications of note.
Insulin lispro is an effective and safe treatment option in gestational diabetes.
AuthorsM C Deepaklal, Kurian Joseph, Rekha Kurian, Nandita A Thakkar
JournalIndian journal of endocrinology and metabolism (Indian J Endocrinol Metab) Vol. 18 Issue 4 Pg. 491-5 (Jul 2014) ISSN: 2230-8210 [Print] India
PMID25143904 (Publication Type: Journal Article)

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