[Multicenter trial for optimization of bolus tracking settings and contrast material injection protocol in arterial dominant phase of dynamic computed tomography for diagnosis of hepatocellular carcinoma].

Abstract

Alongside current improvements in the performance of computer tomography (CT) systems, there has been an increase in the use of bolus tracking (BT) to acquire arterial dominant phase images for dynamic CT at optimal timing for characterization of liver focal lesions. However, optimal BT settings have not been established. In the present study, methods of contrast enhancement and BT setting values were evaluated using a multicenter post-marketing surveillance study on contrast media used in patients with chronic hepatitis and/or cirrhosis who had undergone liver dynamic CT for diagnosis of hepatocellular carcinoma, conducted by Daiichi Sankyo Co., Ltd. The results suggested the contrast injection method to be clinically useful if the amount of iodine per kilogram of body weight is set at 600 mg/kg and the injection duration at 30 s. To achieve a good arterial dominant scan under conditions where the injection duration is fixed at 30 s or the average injection duration is 34 s using the fixed injection rate method, the scan delay time should ideally to be set to longer than 13 s. If using the BT method, we recommend that the BT settings should be revalidated in reference to our results.

• Authors: Shushi Yoshikawa, Masahiro Okada, Hiroshi Kondo, Hironobu Sou, Takamichi Murakami, Masayuki Kanematsu, Tomoaki Ichikawa, Akiko Hayakawa, Kazuhito Shiosakai, Kazuo Awai, Kengo Yoshimitsu, Yasuyuki Yamashita
• Journal: Nihon Hoshasen Gijutsu Gakkai zasshi (Nihon Hoshasen Gijutsu Gakkai Zasshi) Vol. 70 Issue 8 Pg. 805-13 (Aug 2014) ISSN: 0369-4305 [Print] Japan
• PMID: 25142392 (Publication Type: Evaluation Study, Journal Article, Multicenter Study)

Chemical References

• Contrast Media
• Iohexol

Topics

• Aged
• Carcinoma, Hepatocellular (blood supply, diagnostic imaging)
• Contrast Media (administration & dosage)
• Female
• Hepatic Artery (diagnostic imaging)
• Humans
• Injections, Intra-Arterial (methods)
• Iohexol (administration & dosage)
• Liver Neoplasms (blood supply, diagnostic imaging)
• Male
• Middle Aged
• Product Surveillance, Postmarketing
• Tomography, X-Ray Computed (methods)