Fungal siderophore metabolism with a focus on Aspergillus fumigatus.

Abstract

Siderophores are chelators synthesized by microbes to sequester iron. This article summarizes the knowledge on the fungal siderophore metabolism with a focus on Aspergillus fumigatus. In recent years, A. fumigatus became a role model for fungal biosynthesis, uptake and degradation of siderophores as well as regulation of siderophore-mediated iron handling and the elucidation of siderophore functions. Siderophore functions comprise uptake, intracellular transport and storage of iron. This proved to be crucial not only for adaptation to iron starvation conditions but also for germination, asexual and sexual propagation, antioxidative defense, mutual interaction, microbial competition as well as virulence in plant and animal hosts. Recent studies also indicate the high potential of siderophores and its biosynthetic pathway to improve diagnosis and therapy of fungal infections.

• Authors: Hubertus Haas
• Journal: Natural product reports (Nat Prod Rep) Vol. 31 Issue 10 Pg. 1266-76 (Oct 2014) ISSN: 1460-4752 [Electronic] England
• PMID: 25140791 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Siderophores
• Polyketide Synthases

Topics

• Aspergillus fumigatus (chemistry, metabolism)
• Molecular Structure
• Polyketide Synthases (metabolism)
• Siderophores (chemistry, metabolism)