Abstract | BACKGROUND: METHODS: RESULTS: Serum parameters, histopathology and serum cytokine assays showed pronounced features of acute liver failure 12 h after application of acetaminophen ( APAP). Neostigmine treatment led to significant reduction of serum liver enzymes (LDH (47,147 ± 12,726 IU/l vs. 15,822 ± 10,629 IU/l, p = 0.0014) and ALT (18,048 ± 4,287 IU/l vs. 7,585 ± 5,336 IU/l, p = 0.0013), APAP-alone-treated mice vs. APAP + neostigmine-treated mice), inflammatory cytokine levels (IL-1β (147 ± 19 vs. 110 ± 25, p = 0.0138) and TNF-α (184 ± 23 vs. 130 ± 33, p = 0.0086), APAP-alone-treated mice vs. APAP + neostigmine-treated mice) and histopathological signs of damage.Animals treated with NAC in combination with the peripheral cholinesterase inhibitor neostigmine showed prolonged survival and improved outcome. CONCLUSIONS:
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Authors | Niels Steinebrunner, Carolin Mogler, Spiros Vittas, Birgit Hoyler, Catharina Sandig, Wolfgang Stremmel, Christoph Eisenbach |
Journal | BMC gastroenterology
(BMC Gastroenterol)
Vol. 14
Pg. 148
(Aug 19 2014)
ISSN: 1471-230X [Electronic] England |
PMID | 25139304
(Publication Type: Journal Article)
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Chemical References |
- Analgesics, Non-Narcotic
- Cholinesterase Inhibitors
- Free Radical Scavengers
- IL1B protein, mouse
- Interleukin-1beta
- Tumor Necrosis Factor-alpha
- Acetaminophen
- Neostigmine
- Lactate Dehydrogenases
- Alanine Transaminase
- Acetylcysteine
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Topics |
- Acetaminophen
(toxicity)
- Acetylcysteine
(pharmacology)
- Alanine Transaminase
(blood, drug effects)
- Analgesics, Non-Narcotic
(toxicity)
- Animals
- Chemical and Drug Induced Liver Injury
(etiology, immunology, mortality)
- Cholinesterase Inhibitors
(pharmacology)
- Disease Models, Animal
- Free Radical Scavengers
(pharmacology)
- Interleukin-1beta
(drug effects, immunology)
- Lactate Dehydrogenases
(blood, drug effects)
- Liver
(drug effects, immunology)
- Liver Failure, Acute
(chemically induced, immunology, mortality)
- Mice
- Mice, Inbred BALB C
- Neostigmine
(pharmacology)
- Tumor Necrosis Factor-alpha
(drug effects, immunology)
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